Targeting PR1 in myeloid leukemia
نویسندگان
چکیده
منابع مشابه
Targeting PR1 in myeloid leukemia
Acute myeloid leukemia (AML) remains an incurable malignancy. Although the incidence of AML is approximately 20,000 cases annually, the 5-year survival rate remains low at nearly 30%. There are a number of promising therapies for AML currently under development, especially in the relapsed and refractory settings. However, to date, there have been very few breakthroughs in the treatment of relap...
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Objective(s): Chronic myeloid leukemia (CML) is a myeloid clonal proliferation disease defining by the presence of the Philadelphia chromosome that shows the movement of BCR-ABL1. In this study, the critical role of the Musashi2-Numb axis in determining cell fate and relationship of the axis to important signaling pathways such as Hedgehog and Notch that are essential ...
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Drugs targeting metabolism have formed the backbone of therapy for some cancers. We sought to identify new such targets in acute myeloid leukemia (AML). The one-carbon folate pathway, specifically methylenetetrahydrofolate dehydrogenase-cyclohydrolase 2 (MTHFD2), emerged as a top candidate in our analyses. MTHFD2 is the most differentially expressed metabolic enzyme in cancer versus normal cell...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.23403